Mastering Medical
USMLE Step 1 · Renal & Acid-Base

Hyperkalemia ECG vs Hypokalemia ECG

How to tell Hyperkalemia ECG and Hypokalemia ECG apart when a board question makes them look alike.

Fastest separator

Hyperkalemia: peaked T waves progressing to a widened QRS; hypokalemia: flattened T waves with prominent U waves.

Side by side

Hyperkalemia ECGHypokalemia ECG
Key clue

Tall peaked T waves can progress to PR prolongation, P-wave flattening/disappearance, QRS widening, sine-wave rhythm, ventricular arrhythmia, and arrest.

Flattened T waves, ST depression, prominent U waves, and apparent QT/QU prolongation.

Mechanism

High extracellular potassium alters cardiac membrane potentials and progressively slows conduction as levels rise.

Low extracellular potassium delays repolarization and makes U waves more prominent, increasing arrhythmia risk.

Labs and tests

Kidney failure, potassium-sparing drugs, acidosis, tissue breakdown, peaked T waves, or widening QRS points hyperkalemia.

Loop/thiazide use, vomiting, diarrhea, alkalosis, flattened T waves, ST depression, or U waves points hypokalemia.

The trap

Both can cause weakness and arrhythmias, so read the T-QRS-U sequence instead of symptoms alone.

Watch it explained

In the rapid reviewAcid-Base & Renal Tubular Acidosis for USMLE Step 1: Anion Gap Made Easy
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The repair move

For potassium ECGs, scan in order: T wave height, P wave visibility, QRS width, then U waves.

Try a free question

Core

A patient with kidney failure has weakness and an ECG with tall peaked T waves, PR prolongation, small P waves, and widening QRS complexes. Which electrolyte abnormality is most likely?

Show answer and explanation

Answer: A. Hyperkalemia. Hyperkalemia classically causes peaked T waves and can progress to P-wave flattening/disappearance, PR prolongation, QRS widening, and sine-wave rhythm.

Why the other choices are tempting

  • B. Hypokalemia causes flattened T waves, ST depression, and prominent U waves.
  • C. Hypocalcemia prolongs the QT interval.
  • D. Hypernatremia causes neurologic water-balance symptoms, not peaked T waves.
  • E. Hypomagnesemia can predispose to arrhythmias but does not create the classic hyperkalemia pattern.

Flashcards

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What is the early ECG clue for hyperkalemia?

Tall peaked T waves are the classic early clue before conduction slowing becomes severe.

What ECG progression signals severe hyperkalemia?

P waves flatten or disappear, PR may prolong, QRS widens, and a sine-wave pattern can develop.

Quick answers

What is the fastest way to tell Hyperkalemia ECG from Hypokalemia ECG?

Hyperkalemia: peaked T waves progressing to a widened QRS; hypokalemia: flattened T waves with prominent U waves.

What is the key clue for Hyperkalemia ECG?

Tall peaked T waves can progress to PR prolongation, P-wave flattening/disappearance, QRS widening, sine-wave rhythm, ventricular arrhythmia, and arrest.

What is the key clue for Hypokalemia ECG?

Flattened T waves, ST depression, prominent U waves, and apparent QT/QU prolongation.

What is the common trap with Hyperkalemia ECG vs Hypokalemia ECG?

Both can cause weakness and arrhythmias, so read the T-QRS-U sequence instead of symptoms alone.