Hodgkin Reed-Sternberg pattern vs Burkitt starry-sky and mantle cyclin D1 patterns
How to tell Hodgkin Reed-Sternberg pattern and Burkitt starry-sky and mantle cyclin D1 patterns apart when a board question makes them look alike.
Reed-Sternberg/CD15/CD30 means Hodgkin; MYC/starry-sky means Burkitt; cyclin D1/t(11;14) means mantle cell.
Side by side
Hodgkin lymphoma is anchored by Reed-Sternberg cells, CD15/CD30 positivity, mixed inflammatory background, and often contiguous nodal spread.
Burkitt lymphoma is MYC t(8;14) with starry-sky histology and very high proliferation; mantle cell lymphoma is cyclin D1 t(11;14) with CD5-positive B cells.
Malignant Reed-Sternberg cells shape a reactive inflammatory node background.
Burkitt is driven by MYC-mediated proliferation; mantle cell is driven by cyclin D1-mediated cell-cycle progression.
CD15/CD30-positive Reed-Sternberg cells support classic Hodgkin lymphoma.
MYC t(8;14), CD10, and starry-sky histology support Burkitt; cyclin D1, CD5, SOX11, and t(11;14) support mantle cell.
The trap
All are lymphoma clues, so match the named morphology to the marker or translocation.
The repair move
For lymphoma buzzwords, translate the morphology into its marker pair before choosing.
Try a free question
CoreA lymph node biopsy shows large binucleate Reed-Sternberg cells in a mixed inflammatory background. The tumor cells are CD15 and CD30 positive. Which diagnosis is most likely?
Show answer and explanation
Answer: A. Hodgkin lymphoma. Reed-Sternberg cells with CD15/CD30 positivity point to classic Hodgkin lymphoma.
Why the other choices are tempting
- B. Burkitt lymphoma has MYC t(8;14) and starry-sky histology.
- C. Mantle cell lymphoma has cyclin D1 from t(11;14).
- D. Follicular lymphoma has BCL2 from t(14;18).
- E. CML is BCR-ABL myeloid leukemia, not a Reed-Sternberg lymphoma.
Flashcards
Tap a card to flip it.
What marker pair supports classic Hodgkin lymphoma?
CD15 and CD30 positivity in Reed-Sternberg cells supports classic Hodgkin lymphoma.
What histology and translocation support Burkitt lymphoma?
Starry-sky histology with MYC t(8;14) supports Burkitt lymphoma.
Quick answers
What is the fastest way to tell Hodgkin Reed-Sternberg pattern from Burkitt starry-sky and mantle cyclin D1 patterns?
Reed-Sternberg/CD15/CD30 means Hodgkin; MYC/starry-sky means Burkitt; cyclin D1/t(11;14) means mantle cell.
What is the key clue for Hodgkin Reed-Sternberg pattern?
Hodgkin lymphoma is anchored by Reed-Sternberg cells, CD15/CD30 positivity, mixed inflammatory background, and often contiguous nodal spread.
What is the key clue for Burkitt starry-sky and mantle cyclin D1 patterns?
Burkitt lymphoma is MYC t(8;14) with starry-sky histology and very high proliferation; mantle cell lymphoma is cyclin D1 t(11;14) with CD5-positive B cells.
What is the common trap with Hodgkin Reed-Sternberg pattern vs Burkitt starry-sky and mantle cyclin D1 patterns?
All are lymphoma clues, so match the named morphology to the marker or translocation.